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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CASR All Species: 13.64
Human Site: T888 Identified Species: 37.5
UniProt: P41180 Number Species: 8
    Phosphosite Substitution
    Charge Score: -0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P41180 NP_000379.2 1078 120674 T888 F K V A A R A T L R R S N V S
Chimpanzee Pan troglodytes A3QNZ8 839 95029 K660 F Q I V C A F K M A S R F P R
Rhesus Macaque Macaca mulatta A3QP01 839 95041 K660 F Q I V C V F K M A S R F P R
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q9QY96 1079 120821 T888 F K V A A R A T L R R P N I S
Rat Rattus norvegicus P48442 1079 120849 T888 F K V A A R A T L R R P N I S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515899 1088 120096 T888 F K V A A R A T L R R S N L S
Chicken Gallus gallus XP_416491 1059 118051 A877 E V R C S T A A H A F K V A A
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q5U9X3 867 97118 I688 V G M G V Q I I I C T V W L T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P91685 976 108467 T797 L Y N M I L I T I C T I Y A I
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 26.3 25.7 N.A. N.A. 93.6 93.6 N.A. 81.9 85.4 N.A. 30.6 N.A. 26.8 N.A. N.A. N.A.
Protein Similarity: 100 43.5 43.4 N.A. N.A. 96.8 96.9 N.A. 87.8 90.5 N.A. 47.5 N.A. 46.2 N.A. N.A. N.A.
P-Site Identity: 100 6.6 6.6 N.A. N.A. 86.6 86.6 N.A. 93.3 6.6 N.A. 0 N.A. 6.6 N.A. N.A. N.A.
P-Site Similarity: 100 26.6 26.6 N.A. N.A. 93.3 93.3 N.A. 100 20 N.A. 33.3 N.A. 13.3 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 45 45 12 56 12 0 34 0 0 0 23 12 % A
% Cys: 0 0 0 12 23 0 0 0 0 23 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 12 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 67 0 0 0 0 0 23 0 0 0 12 0 23 0 0 % F
% Gly: 0 12 0 12 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 12 0 0 0 0 0 0 % H
% Ile: 0 0 23 0 12 0 23 12 23 0 0 12 0 23 12 % I
% Lys: 0 45 0 0 0 0 0 23 0 0 0 12 0 0 0 % K
% Leu: 12 0 0 0 0 12 0 0 45 0 0 0 0 23 0 % L
% Met: 0 0 12 12 0 0 0 0 23 0 0 0 0 0 0 % M
% Asn: 0 0 12 0 0 0 0 0 0 0 0 0 45 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 23 0 23 0 % P
% Gln: 0 23 0 0 0 12 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 12 0 0 45 0 0 0 45 45 23 0 0 23 % R
% Ser: 0 0 0 0 12 0 0 0 0 0 23 23 0 0 45 % S
% Thr: 0 0 0 0 0 12 0 56 0 0 23 0 0 0 12 % T
% Val: 12 12 45 23 12 12 0 0 0 0 0 12 12 12 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 12 0 0 % W
% Tyr: 0 12 0 0 0 0 0 0 0 0 0 0 12 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _